We also have a guide for the best Leveling Runewords under level 30. If you need more information about individual Runes, including how to acquire them, upgrade them, remove them, and farm them, please see our separate guide:

Blizzard will not restore gear or Runes because you made a mistake! There's no going back once you've put the Runes in, there's no removing them without destroying all your Runes. Runes must be inserted into the correct type of gear, in the correct order, or else it will not create a Runeword and give bonuses. Runewords must be created and inserted carefully into armor and the correct type of weapons. They are not usable for Classic players who choose not to use the expansion.

Runewords are only available for players who are using the full Expansion mode of D2:R, which includes the Lord of Destruction (LoD) expansion. It also presents a complete lists of all known Runewords. This guide will explain how to use Runewords, what kinds of gear will accept them, and how to create them. Welcome to Wowhead's guide to Runewords in Diablo II: Resurrected Patch 2.7 & Ladder Season 4.

Diablo 2 plague runeword